In this article I  am going to implement sorting in asp.net gridview using tablesorter.js 

Step by step 

1.   Open visual studio

2.  Create a web application

3.     Add new page

4.     Drag a gridview on the page

5.     On the head section of page call below script and link

<script src="JS/jquery-1.11.1.js" type="text/javascript"></script>
    <link href="dist/css/theme.default.min.css" rel="stylesheet">
    <script src="dist/js/jquery.tablesorter.min.js"></script>
    <script>
        $(document).ready(function () { 
            $("table").tablesorter();
 
        }); 
    
    </script>

6.     Grid page source like

<asp:GridView ID="GridView1" runat="server" CssClass="tablesorter" CellPadding="4"
            ForeColor="#333333" GridLines="None" OnRowDataBound="GridView1_RowDataBound"  >
            
        </asp:GridView>

 7.     In .cs (code behind) I have create a datatable with some static record and bind to gridview on page load

protected void Page_Load(object sender, EventArgs e) {
        BindGrid();
    }
    private void BindGrid()
    { 
      DataTable table = new DataTable();
        table.Columns.Add("Dosage", typeof(int));
        table.Columns.Add("Drug", typeof(string));
        table.Columns.Add("Patient", typeof(string));
        table.Columns.Add("Date", typeof(DateTime));
 
        // Here we add five DataRows.  
        table.Rows.Add(10, "Hydralazine", "Christoff", DateTime.Now);
        table.Rows.Add(21, "Combivent", "Janet", DateTime.Now);
        table.Rows.Add(100, "Dilantin", "Melanie", DateTime.Now);
        GridView1.DataSource= table;
        GridView1.DataBind();
    }

8.       On gridview rowdatabound event

 protected void GridView1_RowDataBound(object sender, GridViewRowEventArgs e)
    {
        if (this.GridView1.Rows.Count > 0)
        {
            GridView1.UseAccessibleHeader = true;
            GridView1.HeaderRow.TableSection = TableRowSection.TableHeader;
          //  GridView1.FooterRow.TableSection = TableRowSection.TableFooter;
        }
    }

9.    Final result

 Note : for js and plugin go to below  link

http://tablesorter.com/docs/