The fabrication of artificial hearts have got a way in the medical field, the bioengineers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have created a biohybrid model of human ventricles which was successful. The fabrication of human heart is as crucial as a heart which cannot repair itself once injuries have occurred just like the alternative organs. But in order to do so, researchers have to replicate the advanced structure of the heart which includes helical geometrics that is accountable for twisting motions because the heart beats.

HIGHLIGHTS
Bioengineers can create an artificial model of human ventricles
Like other organs, heart cannot be repaired itself after the injuries 
Helical geometrics were responsible for twisting motion according to the heart beat

Well, it has been believed that the twisting motion is very important for pumping blood in high volumes, but the scientists were not able to prove that. This happened partially as making of hearts with totally different geometrics can be tricky. According to the new study as published in Science, scientists are ready to demonstrate that muscle alignment will increase the amount of blood that the ventricles will be able to pump while contracting.

According to the Kit Parker, the Tarr Family Professor of Bioengineering and Applied Physics at SEAS and senior author of the paper have said that “This work may be a major success for organ bio-fabrication and brings it closer to our ultimate goal of building a human heart for transplant.”

In order to reach the conclusion, scientists drummed up a brand new method of additive textile manufacturing, Focused Rotary Jet Spinning (FRJS). Thus it allowed them to fabricate the helically aligned fibres with the diameters starting from many micrometers to several nanometers.

With the model, scientists had tried to check the hypothesis of Edward Sallin, former chair of the Department of Biomathematics at the University of Alabama Birmingham Medical School, who had claimed that helical alignment was vital for big ejection fractions.

A postdoctoral fellow at SEAS and co-author of the study, Huibin Chang has explained that “the human heart really have multiple layers of helically aligned muscles with totally different angles of alignment. With FRJS, it can recreate those advanced structures in an extremely precise method, forming single and even four-chambered ventricle structures.”

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